Yes on a large frameless enclosure, no on a small framed or obscure glass door. Standard clear glass carries a green cast from the iron in it, and that cast strengthens with thickness and panel size. Low iron removes most of it, so white marble stays white. Accurate Glass & Mirror recommends it on large North Jersey enclosures, and on a small tub door almost nobody sees the difference.
Float glass is made with sand, and the iron oxide that comes along with it tints the finished product green. You do not notice it looking at a windowpane because you are looking through an eighth of an inch. You notice it immediately at the exposed edge of a shower panel, which reads a distinct bottle green on standard glass and nearly colorless on low iron.
Thickness is the multiplier. A frameless enclosure in 3/8 or 1/2 inch, viewed on the diagonal across a wide panel, puts a lot of glass between your eye and the tile, and the cast accumulates over that distance. Hold two samples on edge beside each other and the difference stops being a matter of opinion.
The cast shows against anything pale and precisely chosen. White marble, honed limestone, warm whites, soft grays and cool blue tiles all shift under standard glass, and the homeowner who agonized over two white samples is exactly the person who will see it. The same applies to glass shelves, tabletops and mirror, where a polished edge sits in the open.
It hides against dark tile, behind frosted or heavily textured glass, on a small framed tub door, and in a rental or a rarely used guest bath. In those rooms standard clear is not a compromise, it is the correct specification. Lighting tips it either way as well, since a bathroom with a window and pale finishes shows the cast plainly, while a windowless room lit warm conceals a good deal of it.
It is not stronger. Strength comes from thickness and from tempering, not from what the batch was made of, and a low iron panel and a standard panel of the same thickness behave the same way. It is not easier to clean, and it resists water spotting no better than any other glass. Because clarity is precisely what hard water haze ruins, low iron and a protective treatment are usually ordered together. It also costs more than standard clear, which is money worth spending where the difference shows and wasted where it does not.
No. Strength is a function of thickness and of the tempering process, not of color. A 3/8 inch tempered panel performs as a 3/8 inch tempered panel whether it is standard or low iron. The only difference is what your eye picks up looking through the thickness and at the exposed edge.
Over a vanity it is worth considering. A standard mirror sends back a faintly green reflection, which is part of why skin tone and makeup can read cool in one bathroom and warm in another. A low iron mirror returns color much closer to what is standing in front of it. On a closet door, nobody will ever notice.
Nobody settles this from a screen, because a screen cannot show you a glass edge. Standing at the Lodi showroom with standard clear beside low iron answers it faster than any description manages, and it is worth doing while the tile is still being chosen rather than after.
